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Article

Differences and similarities between Drosophila and mammalian 3' end processing of histone pre-mRNAs.

RNA (New York, N.Y.) - 1 Dec 2005

Dominski Zbigniew, Yang Xiao-Cui, Purdy Mathew, Marzluff William F

Abstract excerpt

We used nuclear extracts from Drosophila Kc cells to characterize 3' end processing of Drosophila histone pre-mRNAs. Drosophila SLBP plays a critical role in recruiting the U 7 snRNP to the pre-mRNA and is essential for processing all five Drosophila histone pre-mRNAs. The Drosophila processing machinery strongly prefers cleavage after a fourth nucleotide following the stem-loop and favors an adenosine over...

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Identifiers

PMID: 16251385
DOI: 10.1261/rna.2179305
PMCID: PMC1370872

Genes

SLBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Differences and similarities between Drosophila and mammalian 3' end processing of histone pre-mRNAs.PMID 16251385Read ↗

U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis.Semantic proximity Read ↗

Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA.Semantic proximity Read ↗

Functional importance of conserved nucleotides at the histone RNA 3' processing site.Semantic proximity Read ↗

The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs.Semantic proximity Read ↗

U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein.Semantic proximity Read ↗

In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex.Semantic proximity Read ↗

The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development.Semantic proximity Read ↗

Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.Semantic proximity Read ↗

Multiple processing-defective mutations in a mammalian histone pre-mRNA are suppressed by compensatory changes in U7 RNA both in vivo and in vitro.Semantic proximity Read ↗

A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing.Semantic proximity Read ↗

Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing.Semantic proximity Read ↗

Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.Semantic proximity Read ↗

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