Article
Functional importance of conserved nucleotides at the histone RNA 3' processing site.
RNA (New York, N.Y.) - 1 Mar 1998
Furger A, Schaller A, Schümperli D
Abstract excerpt
Histone pre-mRNA 3' processing is controlled by a hairpin element preceding the processing site that interacts with a hairpin-binding protein (HBP) and a downstream spacer element that serves as anchoring site for the U7 snRNP. In addition, the nucleotides following the hairpin and surrounding the processing site (ACCCA'CA) are conserved among vertebrate histone genes. Single to triple nucleotide mutations of...
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