Article
Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2010
Engel Christoph, Versmold Beatrix, Wappenschmidt Barbara, Simard Jacques, Easton Douglas F, Peock Susan, Cook Margaret, Oliver Clare, Frost Debra, Mayes Rebecca, Evans D Gareth, Eeles Rosalind, Paterson Joan, Brewer Carole, McGuffog Lesley, Antoniou Antonis C, Stoppa-Lyonnet Dominique, Sinilnikova Olga M, Barjhoux Laure, Frenay Marc, Michel Cécile, Leroux Dominique, Dreyfus Helene, Toulas Christine, Gladieff Laurence, Uhrhammer Nancy, Bignon Yves-Jean, Meindl Alfons, Arnold Norbert, Varon-Mateeva Raymonda, Niederacher Dieter, Preisler-Adams Sabine, Kast Karin, Deissler Helmut, Sutter Christian, Gadzicki Dorothea, Chenevix-Trench Georgia, Spurdle Amanda B, Chen Xiaoqing, Beesley Jonathan, Olsson Håkan, Kristoffersson Ulf, Ehrencrona Hans, Liljegren Annelie, van der Luijt Rob B, van Os Theo A, van Leeuwen Flora E, Domchek Susan M, Rebbeck Timothy R, Nathanson Katherine L, Osorio Ana, Ramón y Cajal Teresa, Konstantopoulou Irene, Benítez Javier, Friedman Eitan, Kaufman Bella, Laitman Yael, Mai Phuong L, Greene Mark H, Nevanlinna Heli, Aittomäki Kristiina, Szabo Csilla I, Caldes Trinidad, Couch Fergus J, Andrulis Irene L, Godwin Andrew K, Hamann Ute, Schmutzler Rita K
Abstract excerpt
BACKGROUND: The genes caspase-8 (CASP8) and caspase-10 (CASP10) functionally cooperate and play a key role in the initiation of apoptosis. Suppression of apoptosis is one of the major mechanisms underlying the origin and progression of cancer. Previous case-control studies have indicated that the polymorphisms CASP8 D302H and CASP10 V410I are associated with a reduced risk of breast cancer in the general...
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