Article
The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers.
Breast cancer research and treatment - 1 Feb 2011
Catucci Irene, Verderio Paolo, Pizzamiglio Sara, Manoukian Siranoush, Peissel Bernard, Zaffaroni Daniela, Roversi Gaia, Ripamonti Carla B, Pasini Barbara, Barile Monica, Viel Alessandra, Giannini Giuseppe, Papi Laura, Varesco Liliana, Martayan Aline, Riboni Mirko, Volorio Sara, Radice Paolo, Peterlongo Paolo
Abstract excerpt
The rs3834129 polymorphism, in the promoter of CASP8 gene, has been recently reported as associated with breast cancer risk in the general population, with the minor allele del having a protective effect. Some of the genetic variants found associated with breast cancer risk were reported as risk modifiers in individuals with mutations in BRCA1 and BRCA2 genes. Here, we tested the effect of the rs3834129 del...
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