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Article

Reduced Aph-1b expression causes tissue- and substrate-specific changes in gamma-secretase activity in rats with a complex phenotype.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2006

Coolen Marcel W, van Loo Karen M J, van Bakel Nick N H M, Ellenbroek Bart A, Cools Alexander R, Martens Gerard J M

Abstract excerpt

The gamma-secretase enzyme complex displays intramembrane catalytic activity toward many type I transmembrane proteins, including the Alzheimer-linked amyloid-beta-protein precursor (APP) and the neuregulin receptor ErbB4. Active gamma-secretase is a tetrameric protein complex consisting of presenilin-1 (or -2), nicastrin, PEN-2, and Aph-1a (or -1b). We have recently discovered that pharmacogenetically bred...

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Source

Identifiers

PMID: 16249316
DOI: 10.1096/fj.05-4337fje

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduced Aph-1b expression causes tissue- and substrate-specific changes in gamma-secretase activity in rats with a complex phenotype.PMID 16249316Read ↗

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Differential contribution of the three Aph1 genes to γ-secretase activity <i>in vivo</i>Semantic proximity Read ↗

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic DevelopmentSemantic proximity Read ↗

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.Semantic proximity Read ↗

gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.Semantic proximity Read ↗

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Semantic proximity Read ↗

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Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.Semantic proximity Read ↗

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