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Article

Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders.

Neuron - 17 Feb 2005

Coolen Marcel W, Van Loo Karen M J, Van Bakel Nick N H M, Pulford David J, Serneels Lutgarde, De Strooper Bart, Ellenbroek Bart A, Cools Alexander R, Martens Gerard J M

Abstract excerpt

A combination of genetic factors and early life events is thought to determine the vulnerability of an individual to develop a complex neurodevelopmental disorder like schizophrenia. Pharmacogenetically selected, apomorphine-susceptible Wistar rats (APO-SUS) display a number of behavioral and pathophysiological features reminiscent of such disorders. Here, we report microarray analyses revealing in APO-SUS rats,...

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PMID: 15721236
DOI: 10.1016/j.neuron.2004.12.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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