Article

Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice

2026-06-15

Abstract excerpt

Although prenatal alcohol exposure (PAE) has been proposed as an early-life risk factor for Alzheimer’s disease and related dementias (AD/ADRD), the mechanistic underpinnings are underexplored. Mutations in the Presenilin genes contribute to AD/ADRD, with Presenilin 1 acting as the catalytic subunit of the γ-secretase complex responsible for cleaving Notch and amyloid precursor protein (APP). We hypothesized that...

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Literature Corpus work: 002b2a8d-9d08-52ef-9d83-90ecf003942b
DOI: 10.64898/2026.06.11.731622

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