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APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development

5 Jan 2005

Abstract excerpt

APH-1 (anterior pharynx defective) along with nicastrin and PEN-2 (presenilin enhancer) are essential components of the presenilin (PS)-dependent gamma-secretase complex. There exist three murine Aph-1 alleles termed Aph-1a, Aph-1b, and Aph-1c that encode four distinct APH-1 isoforms: APH-1aL and APH-1aS derived from differential splicing of Aph-1a, APH-1b, and APH-1c. To determine the contributions of mammalian...

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PMID: 15634781
DOI: 10.1523/jneurosci.3814-04.2005

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APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic DevelopmentPMID 15634781Read ↗

Differential contribution of the three Aph1 genes to γ-secretase activity <i>in vivo</i>Semantic proximity Read ↗

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.Semantic proximity Read ↗

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