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Article

Differential contribution of the three Aph1 genes to γ-secretase activity <i>in vivo</i>

21 Jan 2005

Abstract excerpt

Gamma-secretase is the protease responsible for amyloid beta peptide release and is needed for Notch, N-Cadherin, and possibly other signaling pathways. The protease complex consists of at least four subunits, i.e., Presenilin, Aph1, Pen2, and Nicastrin. Two different genes encode Aph1A and Aph1B in man. A duplication of Aph1B in rodents has given rise to a third gene, Aph1C. Different mixes of gamma-secretase...

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PMID: 15665098
DOI: 10.1073/pnas.0408901102

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Differential contribution of the three Aph1 genes to γ-secretase activity <i>in vivo</i>PMID 15665098Read ↗

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