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Article

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling.

eLife - 2 Jun 2014

Fazzari Pietro, Snellinx An, Sabanov Victor, Ahmed Tariq, Serneels Lutgarde, Gartner Annette, Shariati S Ali M, Balschun Detlef, De Strooper Bart

Abstract excerpt

Neuregulin 1 (NRG1) and the γ-secretase subunit APH1B have been previously implicated as genetic risk factors for schizophrenia and schizophrenia relevant deficits have been observed in rodent models with loss of function mutations in either gene. Here we show that the Aph1b-γ-secretase is selectively involved in Nrg1 intracellular signalling. We found that Aph1b-deficient mice display a decrease in excitatory...

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Identifiers

PMID: 24891237
DOI: 10.7554/eLife.02196
PMCID: PMC4073283

Genes

NRG1

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Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling.PMID 24891237Read ↗

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