Article
Allelotype of human thyroid tumors: loss of chromosome 11q13 sequences in follicular neoplasms.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1991
Matsuo K, Tang S H, Fagin J A
Abstract excerpt
Two classes of genes are the targets of mutations involved in human tumorigenesis: oncogenes, the activation of which leads to growth stimulation, and tumor suppressor genes, which become tumorigenic through loss of function, often through allelic deletion. To obtain evidence for a role for tumor...
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- DNA Probes
- DNA, Neoplasm
- Electrophoresis, Polyacrylamide Gel
- Genes, Tumor Suppressor
- Heterozygote
- Humans
- Oncogenes
- Phenotype
- Polymorphism, Genetic
- Thyroid Neoplasms