Article
Allelotype of human thyroid tumors: loss of chromosome 11q13 sequences in follicular neoplasms.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1991
Matsuo K, Tang S H, Fagin J A
Abstract excerpt
Two classes of genes are the targets of mutations involved in human tumorigenesis: oncogenes, the activation of which leads to growth stimulation, and tumor suppressor genes, which become tumorigenic through loss of function, often through allelic deletion. To obtain evidence for a role for tumor suppressor genes in thyroid tumorigenesis, we examined DNA from 80 thyroid neoplasms for loss of heterozygosity in...
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