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Article

Rearranging the centromere of the human Y chromosome with phiC31 integrase.

Nucleic acids research - 1 Jan 2005

Malla Sunir, Dafhnis-Calas Felix, Brookfield John F Y, Smith Margaret C M, Brown William R A

Abstract excerpt

We have investigated the ability of the integrase from the Streptomyces phiC31 'phage to either delete or invert 1 Mb of DNA around the centromere of the human Y chromosome in chicken DT40 hybrid somatic cells. Reciprocal and conservative site-specific recombination was observed in 54% of cells expressing the integrase. The sites failed to recombine in the remaining cells because the sites had been damaged. The...

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Identifiers

PMID: 16246911
DOI: 10.1093/nar/gki922
PMCID: PMC1266074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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