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Article

Site-specific recombination in human cells catalyzed by phage lambda integrase mutants.

Journal of molecular biology - 10 Mar 2000

Lorbach E, Christ N, Schwikardi M, Droge P

Abstract excerpt

Phage lambda Integrase (Int) is the prototype of the so-called integrase family of conservative site-specific recombinases, which includes Cre and FLP. The natural function of Int is to execute integration and excision of the phage into and out of the Escherichia coli genome, respectively. In contrast to Cre and FLP, however, wild-type Int requires accessory proteins and DNA supercoiling of target sites to...

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PMID: 10698624
DOI: 10.1006/jmbi.2000.3532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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