Article
New mammalian cellular systems to study mutations introduced at the break site by non-homologous end-joining.
DNA repair - 2 May 2005
Rebuzzini Paola, Khoriauli Lela, Azzalin Claus M, Magnani Elisa, Mondello Chiara, Giulotto Elena
Abstract excerpt
The non-homologous end-joining (NHEJ) pathway is a mechanism to repair DNA double strand breaks, which can introduce mutations at repair sites. We constructed new cellular systems to specifically analyze sequence modifications occurring at the repair site. In particular, we looked for the presence of telomeric repeats at the repair junctions, since our previous work indicated that telomeric sequences could be...
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