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Article

Cell type differences in activity of the Streptomyces bacteriophage C31 integrase

21 Aug 2008

Abstract excerpt

Genomic integration by the Streptomyces bacteriophage C31 integrase is a promising tool for non-viral gene therapy of various genetic disorders. We investigated the C31 integrase recombination activity in T cell derived cell lines, primary T lymphocytes and CD34(+) haematopoietic stem cells in comparison to mesenchymal stem cells and cell lines derived from lung-, liver- and cervix-tissue. In T cell lines,...

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PMID: 18718925
DOI: 10.1093/nar/gkn532

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