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Article

Plasmid-mediated induction of recombination in yeast.

Genetics - 1 May 1994

Silberman R, Kupiec M

Abstract excerpt

Diploid yeast cells heteroallelic at the HIS3 locus were transformed with a minichromosome (centromeric plasmid) carrying homology to the HIS3 region and containing the same two mutations as were present in the chromosomes. When a double-strand break (DSB) was introduced in the region of homology, an increase in the recombination frequency between heteroalleles (leading to His+ cells) was observed, although the...

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Identifiers

PMID: 8056321
DOI: 10.1093/genetics/137.1.41
PMCID: PMC1205951

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Source receipt: pubmed, retrieved 7 Sept 2026.

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