Article
DNA binding and synapsis by the large C-terminal domain of phiC31 integrase.
Nucleic acids research - 1 Aug 2009
McEwan Andrew R, Rowley Paul A, Smith Margaret C M
Abstract excerpt
The integrase (Int) from phage C31 acts on the phage and host-attachment sites, attP and attB, to form an integrated prophage flanked by attL and attR. Excision (attL x attR recombination) is prevented, in the absence of accessory factors, by a putative coiled-coil motif in the C-terminal domain (CTD). Int has a serine recombinase N-terminal domain, required for synapsis of recombination substrates and catalysis....
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