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Article

Structure-guided design of a novel, stable, and soluble Cecropin A variant for antimicrobial therapeutic applications

2025-07-21

Abstract excerpt

<title>Abstract</title> <p>Cecropin A is a potent antimicrobial peptide with broad-spectrum activity; however, its clinical application is limited by poor stability, solubility, and bioavailability. In this study, an engineered analog of Cecropin A was developed by incorporating an M cell-targeting peptide (MTP) at the N-terminus, a self-assembling EAK16-II sequence at the C-terminus, and a rigid EAAAK linker to...

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Literature Corpus work
893c64d2-740f-5f73-8335-1104d3c3e372
DOI
10.21203/rs.3.rs-6996527/v1
Open publication

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Structure-guided design of a novel, stable, and soluble Cecropin A variant for antimicrobial therapeutic applicationsDOI 10.21203/rs.3.rs-6996527/v1
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