Article
DNA microarray genotyping of N-acetyltransferase 2 polymorphism using carbodiimide as the linker for assessment of isoniazid hepatotoxicity.
Tuberculosis (Edinburgh, Scotland) - 1 Sept 2006
Shimizu Yasuo, Dobashi Kunio, Mita Yoshihiro, Endou Katsuaki, Moriya Shogo, Osano Kaoru, Koike Yoko, Higuchi Seiichi, Yabe Shigeki, Utsugi Mitsuyoshi, Ishizuka Tamotsu, Hisada Takeshi, Nakazawa Tsugio, Mori Masatomo
Abstract excerpt
The antituberculous drug isoniazid (INH) is acetylated by N-acetyltransferase 2 (NAT2), and the frequency of INH-induced hepatotoxicity is determined by the NAT2 genotype. NAT2 genotyping is not done routinely in hospital laboratories because of its difficulty. Use of microarrays for research is becoming common and its expectations of clinical application are increasing. In this study, we attempted to develop an...
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