Article
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis.
Hepatology (Baltimore, Md.) - 1 Apr 2002
Huang Yi-Shin, Chern Herng-Der, Su Wei-Juin, Wu Jaw-Ching, Lai Shinn-Liang, Yang Shi-Yi, Chang Full-Young, Lee Shou-Dong
Abstract excerpt
Antituberculosis drug-induced hepatitis is one of the most prevalent drug-induced liver injuries. Isoniazid is the major drug incriminated in this hepatotoxicity. Isoniazid is mainly metabolized to hepatotoxic intermediates by N-acetyltransferase (NAT). However, the association of polymorphic NAT acetylator status and antituberculosis drug-induced hepatitis is debatable. To determine whether acetylator status is...
Topics
- Acetylation
- Aged
- Aging
- Antitubercular Agents
- Arylamine N-Acetyltransferase
- Chemical and Drug Induced Liver Injury
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Isoniazid
- Male
- Middle Aged