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Article

Microarray-based pncA genotyping of pyrazinamide-resistant strains of Mycobacterium tuberculosis.

Journal of medical microbiology - 1 Dec 2005

Denkin Steven, Volokhov Dmitriy, Chizhikov Vladimir, Zhang Ying

Abstract excerpt

Drug-resistant Mycobacterium tuberculosis poses a significant threat to the treatment of tuberculosis (TB). The current susceptibility testing for the first-line TB drug pyrazinamide (PZA) is not only time-consuming but also difficult, due to the requirement for acid pH for drug activity. Predominantly, resistance to PZA in M. tuberculosis is caused by mutations in the pncA gene, and the detection of pncA...

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Source

Identifiers

PMID: 16278424
DOI: 10.1099/jmm.0.46129-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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