Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.

doi:10.1242/dev.125.14.2533

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Article

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.

Development (Cambridge, England) - 1 Jul 1998

Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, Hui C C

Abstract excerpt

Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by notochord, whereas motor neurons are thought to be specified by a lower level activity of Shh secreted in turn by floor plate cells. In Drosophila, the Gli zinc finger prot...

Topics

Animals
Cell Differentiation
DNA-Binding Proteins
Down-Regulation
Embryo, Mammalian
Eye Proteins
Gene Expression Regulation, Developmental
Hedgehog Proteins
Hepatocyte Nuclear Factor 3-beta
Homeodomain Proteins
Kruppel-Like Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mice

Mice, Knockout

Motor Neurons

Mutation

Nerve Tissue Proteins

Neural Crest

Source

Open in PubMed

Identifiers

PMID: 9636069
DOI: 10.1242/dev.125.14.2533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9636069-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.PMID 9636069Read ↗

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