Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.

Development (Cambridge, England) - 1 Jul 1998

Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, Hui C C

Abstract excerpt

Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by notochord, whereas motor neurons are thought to be specified by a lower level activity of Shh secreted in turn by floor plate cells. In Drosophila, the Gli zinc finger protein Cubitus interruptus functions as a transcription factor activating Hedgehog-responsive genes. We report that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Cell Differentiation
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Homeodomain Proteins

Share to Membrane Proteins

Share to Mutation

Share to Nerve Tissue Proteins

Source

Identifiers

PMID: 9636069
DOI: 10.1242/dev.125.14.2533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.PMID 9636069Read ↗

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.Semantic proximity Read ↗

Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog.Semantic proximity Read ↗

Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.Semantic proximity Read ↗

Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant.Semantic proximity Read ↗

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.Semantic proximity Read ↗

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.Semantic proximity Read ↗

Gli function is essential for motor neuron induction in zebrafish.Semantic proximity Read ↗

Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development.Semantic proximity Read ↗

Zebrafish wnt4b expression in the floor plate is altered in sonic hedgehog and gli-2 mutants.Semantic proximity Read ↗

Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.Semantic proximity Read ↗

Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse.Semantic proximity Read ↗

The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.