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Article

Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.

Human molecular genetics - 1 Oct 2008

Warr Nicholas, Powles-Glover Nicola, Chappell Anna, Robson Joan, Norris Dominic, Arkell Ruth M

Abstract excerpt

The putative transcription factor ZIC2 is associated with a defect of forebrain development, known as Holoprosencephaly (HPE), in humans and mouse, yet the mechanism by which aberrant ZIC2 function causes classical HPE is unexplained. The zinc finger domain of all mammalian Zic genes is highly homologous with that of the Gli genes, which are transcriptional mediators of Shh signalling. Mutations in Shh and many...

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Source

Identifiers

PMID: 18617531
DOI: 10.1093/hmg/ddn197

Genes

ZIC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.PMID 18617531Read ↗

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