Article
Phenotype-dependent functional and pharmacological properties of BK channels in skeletal muscle: effects of microgravity.
Neurobiology of disease - 1 Nov 2005
Tricarico Domenico, Mele Antonietta, Conte Camerino Diana
Abstract excerpt
We investigated the involvement of calcium-activated potassium channel (BK) in skeletal muscle phenotype determination and response to acetazolamide, a BK opener. The BKs of slow-twitching soleus (SOL) and fast-twitching flexor digitorum brevis (FDB) muscles of the rat were investigated by patch-clamp technique. The changes of BK properties following muscle disuse were investigated in the hindlimb-unloaded (HU)...
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