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Article

Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle.

Biochimica et biophysica acta - 1 Apr 2013

Mateja Ryan D, Greaser Marion L, de Tombe Pieter P

Abstract excerpt

The magnitude of length dependent activation in striated muscle has been shown to vary with titin isoform. Recently, a rat that harbors a homozygous autosomal mutation (HM) causing preferential expression of a longer, giant titin isoform was discovered (Greaser et al. 2005). Here, we investigated the impact of titin isoform on myofilament force development and cross-bridge cycling kinetics as function of...

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Identifiers

PMID: 22951219
DOI: 10.1016/j.bbamcr.2012.08.011
PMCID: PMC3518735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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