Article
Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle.
Biochimica et biophysica acta - 1 Apr 2013
Mateja Ryan D, Greaser Marion L, de Tombe Pieter P
Abstract excerpt
The magnitude of length dependent activation in striated muscle has been shown to vary with titin isoform. Recently, a rat that harbors a homozygous autosomal mutation (HM) causing preferential expression of a longer, giant titin isoform was discovered (Greaser et al. 2005). Here, we investigated the impact of titin isoform on myofilament force development and cross-bridge cycling kinetics as function of...
Topics
- Actin Cytoskeleton
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Animals
- Calcium
- Connectin
- Gene Expression
- Homozygote
- Isometric Contraction
- Kinetics
- Muscle Proteins
- Muscle Relaxation
- Muscle Tonus
- Muscle, Skeletal
- Mutation