Article
Myonuclear domain and myosin phenotype in human soleus after bed rest with or without loading.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Nov 1999
Ohira Y, Yoshinaga T, Ohara M, Nonaka I, Yoshioka T, Yamashita-Goto K, Shenkman B S, Kozlovskaya I B, Roy R R, Edgerton V R
Abstract excerpt
After 2 or 4 mo of bed rest (6 degrees head-down tilt) and 1 mo of ambulation, there was a tendency toward a higher percentage of fibers expressing fast myosin heavy chain (MHC) isoforms and a de novo appearance of fibers coexpressing type I+IIa+IIx and IIa+IIx MHC in human soleus fibers. After 2 and 4 mo of bed rest, the mean size of type I fibers decreased by 12 (P > 0.05) and 39%, respectively. Because...
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