Article
Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease.
Disease models & mechanisms - 1 Mar 2017
Hasham Muneer G, Baxan Nicoleta, Stuckey Daniel J, Branca Jane, Perkins Bryant, Dent Oliver, Duffy Ted, Hameed Tolani S, Stella Sarah E, Bellahcene Mohammed, Schneider Michael D, Harding Sian E, Rosenthal Nadia, Sattler Susanne
Abstract excerpt
Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) show significant heart involvement and cardiovascular morbidity, which can be due to systemically increased levels of inflammation or direct autoreactivity targeting cardiac tissue. Despite high clinical relevance, cardiac damage secondary to systemic autoimmunity lacks inducible rodent models. Here, we...
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