Article
Statins as modulators of regulatory T-cell biology.
Mediators of inflammation - 1 Jan 2013
Forero-Peña David A, Gutierrez Fredy R S
Abstract excerpt
Statins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol. Some recent experimental studies have shown that besides their effects on the primary and secondary prevention of cardiovascular diseases, statins may also have beneficial anti-inflammatory effects through diverse mechanisms. On the other hand, the...
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