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Article

Structural determinants of pharmacological specificity between D(1) and D(2) dopamine receptors.

Molecular pharmacology - 1 Jan 2006

Lan Hongxiang, Durand Curtiss J, Teeter Martha M, Neve Kim A

Abstract excerpt

To test the hypothesis that pharmacological differentiation between D(1) and D(2) dopamine receptors results from interactions of selective ligands with nonconserved residues lining the binding pocket, we mutated amino acid residues in the D(2) receptor to the corresponding aligned residues in the D(1) receptor and vice versa and expressed the receptors in human embryonic kidney 293 cells. Determinations of the...

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PMID: 16236817
DOI: 10.1124/mol.105.017244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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