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Article

Three amino acids in the D2 dopamine receptor regulate selective ligand function and affinity.

Journal of neurochemistry - 1 Jul 2009

Cummings David F, Ericksen Spencer S, Schetz John A

Abstract excerpt

The D(2) dopamine receptor is an important therapeutic target for the treatment of psychotic, agitated, and abnormal behavioral states. To better understand the specific interactions of subtype-selective ligands with dopamine receptor subtypes, seven ligands with high selectivity (>120-fold) for the D(4) subtype of dopamine receptor were tested on wild-type and mutant D(2) receptors. Five of the selective ligands...

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Source

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Identifiers

PMID: 19486266
DOI: 10.1111/j.1471-4159.2009.06103.x
PMCID: PMC4896224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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