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Article

Dopamine D2 Receptor Agonist Binding Kinetics-Role of a Conserved Serine Residue.

International journal of molecular sciences - 15 Apr 2021

Ågren Richard, Stepniewski Tomasz Maciej, Zeberg Hugo, Selent Jana, Sahlholm Kristoffer

Abstract excerpt

The forward (kon) and reverse (koff) rate constants of drug-target interactions have important implications for therapeutic efficacy. Hence, time-resolved assays capable of measuring these binding rate constants may be informative to drug discovery efforts. Here, we used an ion channel activation assay to estimate the kons and koffs of four dopamine D2 receptor (D2R) agonists; dopamine (DA), p-tyramine, (R)- and...

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Share to Conserved Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33920848
DOI: 10.3390/ijms22084078
PMCID: PMC8071183

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