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Article

Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes.

Journal of medicinal chemistry - 10 Feb 2005

Boeckler Frank, Lanig Harald, Gmeiner Peter

Abstract excerpt

Focusing on the similarity and divergence of GPCR subtypes and their ligand interactions, we generated dopamine D2, D3, and D4 receptor models based on the rhodopsin crystal structure and refined these with an extensive MM/MD protocol. After validation by diagnostic experimental data, subtype-specific relative positions of TM1, 2, 6, and 7 and bending angles of TM7 were found. To sample the conformational space...

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Identifiers

PMID: 15689154
DOI: 10.1021/jm049612a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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