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Article

ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.

The Journal of biological chemistry - 16 Dec 2005

Noguchi Masakatsu, Takata Takahiro, Kimura Yoko, Manno Atsushi, Murakami Katsuhiro, Koike Masaaki, Ohizumi Hiroshi, Hori Seiji, Kakizuka Akira

Abstract excerpt

Valosin-containing protein (p97/VCP) has been proposed as playing crucial roles in a variety of physiological and pathological processes such as cancer and neurodegeneration. We previously showed that VCP(K524A), an ATPase activity-negative VCP mutant, induced vacuolization, accumulation of ubiquitinated proteins, and cell death, phenotypes commonly observed in neurodegenerative disorders. However, any regulatory...

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Identifiers

PMID: 16234241
DOI: 10.1074/jbc.M509700200

Genes

VCP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.PMID 16234241Read ↗

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