Article
Valosin-Containing Protein (VCP)/p97 Oligomerization.
Sub-cellular biochemistry - 1 Jan 2024
Yu Guimei, Bai Yunpeng, Zhang Zhong-Yin
Abstract excerpt
Valosin-containing protein (VCP), also known as p97, is an evolutionarily conserved AAA+ ATPase essential for cellular homeostasis. Cooperating with different sets of cofactors, VCP is involved in multiple cellular processes through either the ubiquitin-proteasome system (UPS) or the autophagy/lysosomal route. Pathogenic mutations frequently found at the interface between the NTD domain and D1 ATPase domain have...
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