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Article

Valosin-Containing Protein (VCP): A Review of Its Diverse Molecular Functions and Clinical Phenotypes.

International journal of molecular sciences - 22 May 2024

Pontifex Carly S, Zaman Mashiat, Fanganiello Roberto D, Shutt Timothy E, Pfeffer Gerald

Abstract excerpt

In this review we examine the functionally diverse ATPase associated with various cellular activities (AAA-ATPase), valosin-containing protein (VCP/p97), its molecular functions, the mutational landscape of VCP and the phenotypic manifestation of VCP disease. VCP is crucial to a multitude of cellular functions including protein quality control, endoplasmic reticulum-associated degradation (ERAD), autophagy,...

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Identifiers

PMID: 38891822
DOI: 10.3390/ijms25115633
PMCID: PMC11172259

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