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Article

p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol.

Science advances - 3 May 2024

Wrobel Lidia, Hoffmann Johanna L, Li Xinyi, Rubinsztein David C

Abstract excerpt

The AAA+-ATPase valosin-containing protein (VCP; also called p97 or Cdc48), a major protein unfolding machinery with a variety of essential functions, localizes to different subcellular compartments where it has different functions. However, the processes regulating the distribution of VCP between the cytosol and nucleus are not understood. Here, we identified p37 (also called UBXN2B) as a major factor regulating...

Topics

Valosin Containing Protein
Humans
Cytosol
Cell Nucleus
Mutation
Active Transport, Cell Nucleus
DNA Damage
Adenosine Triphosphatases
Cell Cycle Proteins
Protein Transport
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Repair

Autophagy

Protein Binding

HEK293 Cells

Adaptor Proteins, Signal Transducing

Source

Open in PubMed Open full text

Identifiers

PMID: 38701207
DOI: 10.1126/sciadv.adl6082
PMCID: PMC11068011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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