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Article

Characterization of the aggregation-prevention activity of p97/valosin-containing protein.

Biochemistry - 25 Dec 2007

Song Changcheng, Wang Qing, Li Chou-Chi H

Abstract excerpt

The 97 kDa valosin-containing protein (VCP) belongs to a highly conserved AAA (ATPases associated with a variety of activities) family and contains two ATPase domains, D1 and D2. VCP participates in numerous cellular activities, such as membrane fusion, postmitotic Golgi reassembly, endoplasmic reticulum-associated degradation, ubiquitin-proteasome-mediated proteolysis, and many others. In performing these...

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Identifiers

PMID: 18044963
DOI: 10.1021/bi700499j

Genes

VCP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Characterization of the aggregation-prevention activity of p97/valosin-containing protein.PMID 18044963Read ↗

Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.Semantic proximity Read ↗

ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.Semantic proximity Read ↗

p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.Semantic proximity Read ↗

Valosin-Containing Protein (VCP)/p97 Oligomerization.Semantic proximity Read ↗

Valosin-Containing Protein (VCP): A Review of Its Diverse Molecular Functions and Clinical Phenotypes.Semantic proximity Read ↗

Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in CancerSemantic proximity Read ↗

Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases.Semantic proximity Read ↗

D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.Semantic proximity Read ↗

Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities.Semantic proximity Read ↗

p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral InfectionsSemantic proximity Read ↗

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesisSemantic proximity Read ↗

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.Semantic proximity Read ↗

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