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Article

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.

Nature cell biology - 2 Feb 2012

Meyer Hemmo, Bug Monika, Bremer Sebastian

Abstract excerpt

The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in ubiquitin-dependent protein quality control and intracellular signalling pathways. It cooperates with diverse partner proteins to help process ubiquitin-labelled proteins for recycling or degradation by the proteasome in many cellular contexts. Recent studies have uncovered unexpected cellular functions for p97 in autophagy,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22298039
DOI: 10.1038/ncb2407

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.PMID 22298039Read ↗

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Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.Semantic proximity Read ↗

Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in CancerSemantic proximity Read ↗

p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol.Semantic proximity Read ↗

Recent advances in p97/VCP/Cdc48 cellular functions.Semantic proximity Read ↗

p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral InfectionsSemantic proximity Read ↗

Valosin-Containing Protein (VCP)/p97 Oligomerization.Semantic proximity Read ↗

D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.Semantic proximity Read ↗

AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation.Semantic proximity Read ↗

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