Article
p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2009
Mori-Konya Chiho, Kato Naruyoshi, Maeda Ryota, Yasuda Kunihiko, Higashimae Naoki, Noguchi Masakatsu, Koike Masaaki, Kimura Yoko, Ohizumi Hiroshi, Hori Seiji, Kakizuka Akira
Abstract excerpt
p97/valosin-containing protein (VCP) is a member of the AAA family proteins, which plays various important roles in cells by using its ATPase activity. But mechanism of regulating its ATPase activity is mostly unknown. We report here that VCP is highly modified throughout the protein via acetylation and phosphorylation. In addition to six previously identified phosphorylation sites, we identified at least 14...
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