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Article

Effects of an epilepsy-causing mutation in the SCN1A sodium channel gene on cocaine-induced seizure susceptibility in mice.

Psychopharmacology - 1 Jul 2013

Purcell Ryan H, Papale Ligia A, Makinson Christopher D, Sawyer Nikki T, Schroeder Jason P, Escayg Andrew, Weinshenker David

Abstract excerpt

RATIONALE: High doses of cocaine can elicit seizures in humans and in laboratory animals. Several mechanisms have been proposed for the induction of seizures by cocaine, including enhanced monoaminergic signaling, blockade of ion channels, and alterations in GABA and glutamate transmission. Mutations in the SCN1A gene, which encodes the central nervous system (CNS) voltage-gated sodium channel (VGSC) Nav1.1, are...

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Source

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Identifiers

PMID: 23494229
DOI: 10.1007/s00213-013-3034-8
PMCID: PMC3695079

Genes

SCN1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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