Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains.

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Article

Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2000

Hain H S, Crabbe J C, Bergeson S E, Belknap J K

Abstract excerpt

Seizures are a well known consequence of human cocaine abuse, and in rodent models, sensitivity to cocaine seizures has been shown to be strongly influenced by genotype. For example, several studies have reported significant differences between the C57BL/6 (B6) and DBA/2 (D2) inbred mouse strains in their sensitivity to cocaine-induced seizures. This prompted our use of the BXD recombinant inbred (RI) strain set...

Topics

Animals
Chromosome Mapping
Chromosomes
Cocaine
Dopamine Uptake Inhibitors
Epilepsy, Tonic-Clonic
Female
Genotype
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Seizures
Species Specificity

Source

Open in PubMed

Identifiers

PMID: 10734168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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