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Article

Analysis of an association between the COMT polymorphism and clinical symptomatology in schizophrenia.

Neuroscience letters - 30 Jan 2006

Strous Rael D, Lapidus Raya, Viglin Dina, Kotler Moshe, Lachman Herbert M

Abstract excerpt

Based on their metabolic inactivation of dopamine and norepinephrine, genes encoding the catechol-O-methyltransferase (COMT) enzyme are appropriate candidates to consider in the pathogenesis of schizophrenia. COMT enzyme activity is regulated by a common polymorphism causing substantial variations in enzymatic activity, and evidence for allelic or genotypic association with cognitive and behavioral features of...

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Source

Identifiers

PMID: 16233957
DOI: 10.1016/j.neulet.2005.09.067

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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