Article
No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population.
Molecular biology reports - 1 Feb 2013
Tovilla-Zárate Carlos, Medellín Beatriz Camarena, Fresán Ana, López-Narváez Lilia, Castro Thelma Beatriz Gonzalez, Juárez Rojop Isela, Ramírez-Bello Julián, Genis Alma, Nicolini Humberto
Abstract excerpt
The gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. We determined the relation of the COMT Val108/158Met polymorphism with schizophrenia or its symptomatology (negative, disorganized and psychotic dimension). We conducted a case-control study comprising 186 patients with schizophrenia and 247...
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