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Impact of MDM2 single nucleotide polymorphism on oral squamous cell carcinoma risk.

Cell biochemistry and biophysics - 1 Mar 2015

Xie Jian-Li, Yang Jing-Lei, Liu De-Sheng, Xie Yong-Gang, Ji Ping

Abstract excerpt

Mouse Double Minute 2 (MDM2) has emerged as a pivotal cellular antagonist of p53 by destructing the suppressive function of p53 against tumorigenesis. The MDM2 309 T > G polymorphism has been studied for its association with oral squamous cell carcinoma (OSCC) susceptibility, but the evidence was confusing and inconclusive. Here, we performed a meta-analysis to estimate the effects of the 309 T > G polymorphism...

Topics

Carcinoma, Squamous Cell
Genetic Predisposition to Disease
Humans
Mouth Neoplasms
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-mdm2

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25323564
DOI: 10.1007/s12013-014-0298-5

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Impact of MDM2 single nucleotide polymorphism on oral squamous cell carcinoma risk.PMID 25323564Read ↗

MDM2 309T>G polymorphism and risk of squamous cell carcinomas of head and neck: a meta-analysis.Semantic proximity Read ↗

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