Article
Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice.
The Journal of nutrition - 1 Sept 2008
Yang Kan, Lamprecht Sergio A, Shinozaki Hiroharu, Fan Kunhua, Yang Wancai, Newmark Harold L, Kopelovich Levy, Edelmann Winfried, Jin Bo, Gravaghi Claudia, Augenlicht Leonard, Kucherlapati Raju, Lipkin Martin
Abstract excerpt
Both epidemiological and experimental findings have indicated that components of Western diets influence colonic tumorigenesis. Among dietary constituents, calcium and cholecalciferol have emerged as promising chemopreventive agents. We have demonstrated that a Western-style diet (WD) with low levels of calcium and cholecalciferol and high levels of (n-6) PUFA, increased the incidence of neoplasia in mouse...
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