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Article

Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse.

Developmental biology - 15 Nov 2005

Czyzyk Traci A, Ning Yun, Hsu Ming-Sing, Peng Bonnie, Mains Richard E, Eipper Betty A, Pintar John E

Abstract excerpt

Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the COOH-terminal amidation of peptide hormones. We previously had found high expression of PAM in several regions of the developing rodent. To determine the function of PAM during mouse embryogenesis, we produced a null mutant of the PAM gene. Homozygous mutants die in utero between e14.5 and e15.5 with severe edema that is likely due to...

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Source

Identifiers

PMID: 16225857
DOI: 10.1016/j.ydbio.2005.09.001

Genes

PAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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