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Article

Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008

Fernández Ana P, Serrano Julia, Tessarollo Lino, Cuttitta Frank, Martínez Alfredo

Abstract excerpt

The adrenomedullin (AM) gene, adm, is widely expressed in the central nervous system (CNS) and several functions have been suggested for brain AM. Until now, a formal confirmation of these actions using genetic models has been elusive since the systemic adm knockout results in embryo lethality. We have built a conditional knockout mouse model using the Cre/loxP approach. When crossed with transgenic mice...

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Identifiers

PMID: 18723674
DOI: 10.1073/pnas.0803174105
PMCID: PMC2527954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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