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Article

Gene expression and pathway analysis of effects of the CMAH deactivation on mouse lung, kidney and heart.

PloS one - 1 Jan 2014

Kwon Deug-Nam, Chang Byung-Soo, Kim Jin-Hoi

Abstract excerpt

BACKGROUND: N-glycolylneuraminic acid (Neu5Gc) is generated by hydroxylation of CMP-Neu5Ac to CMP-Neu5Gc, catalyzed by CMP-Neu5Ac hydroxylase (CMAH). However, humans lack this common mammalian cell surface molecule, Neu5Gc, due to inactivation of the CMAH gene during evolution. CMAH is one of several human-specific genes whose function has been lost by disruption or deletion of the coding frame. It has been...

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PMID: 25229777
DOI: 10.1371/journal.pone.0107559
PMCID: PMC4167996

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