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Article

Homocysteine levels, MTHFR C677T genotype, and MRI Hyperintensities in late-onset major depressive disorder.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Oct 2005

Chen Cheng-Sheng, Tsai Jer-Chia, Tsang Hin-Yeung, Kuo Yu-Ting, Lin Hsiu-Fen, Chiang I-Chan, Devanand D P

Abstract excerpt

OBJECTIVE: Epidemiological studies suggest that elevated plasma homocysteine is associated with an increased risk of depression and cerebrovascular disease. There are no published reports of homocysteine levels and methylenetetrahydrofolate reductase (MTHFR) C677T genotype in clinical samples of patients with late-onset major depressive disorder (MDD). The purpose of this study was to examine the association of...

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PMID: 16223965
DOI: 10.1176/appi.ajgp.13.10.869

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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