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Article

The homocysteine hypothesis of depression.

The American journal of psychiatry - 1 Jun 2007

Folstein Marshal, Liu Timothy, Peter Inga, Buell Jennifer, Buel Jennifer, Arsenault Lisa, Scott Tammy, Qiu Wendy W

Abstract excerpt

High levels of homocysteine are associated with cerebrovascular disease, monoamine neurotransmitters, and depression of mood. A plausible hypothesis for these associations is that high homocysteine levels cause cerebral vascular disease and neurotransmitter deficiency, which cause depression of mood. The homocysteine depression hypothesis, if true, would mandate inclusions of imaging studies for cerebrovascular...

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Source

Identifiers

PMID: 17541043
DOI: 10.1176/ajp.2007.164.6.861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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